![]() ![]() Moreover, subcutaneously injected antisense oligonucleotide against ARL4C into tumor-bearing mice suppressed metastasis of pancreatic cancer. Specific localization of ARL4C, IQGAP1, and MMP14 was the active site of invasion, which induced degradation of the extracellular matrix. ![]() ARL4C recruited IQGAP1 and its downstream effector, MMP14, to invasive pseudopods. IQGAP1 was identified as a novel interacting protein for ARL4C. In the present study, we found that ARL4C is frequently overexpressed in pancreatic cancer patients and showed that its localization to invasive pseudopods is required for cancer cell invasion. ARL4C is a small G protein whose expression is induced by the Wnt and EGF–RAS pathways. Whereas KRAS is mutated in most pancreatic cancer patients, controlling KRAS or its downstream effectors has not been succeeded clinically. Pancreatic cancer has a high mortality rate due to metastasis. ![]()
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